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The Basilica of Our Lady of Guadalupe in Mexico City, Mexico, is the world’s most-visited Catholic shrine, drawing over 10 million pilgrims annually to venerate the Virgin Mary’s miraculous image on St. Juan Diego’s tilma from her 1531 apparitions. Established as a basilica in 1904, it houses the tilma in a modern basilica (1976) and serves as the heart of Mexican Catholicism, blending indigenous and Catholic traditions. Its role as Patroness of the Americas makes it a global symbol of faith and inculturation in a nation of 100–110 million Catholics.